منابع مشابه
Antitumor activity via inhibition of glycosphingolipid biosynthesis.
The production by cancer cells of glycolipids, perhaps derived partly from host glycolipids, may play essential roles in malignancy, tumor growth, immunity from host immunodefense, and metastasis. The glycolipids are derived from the primary glycolipid, glucosylceramide (GlcCer), which is formed enzymatically from ceramide and uridine diphosphoglucose (UDP-glu). Injection of an inhibitor of thi...
متن کاملRegulation of membrane-bound enzymes of glycosphingolipid biosynthesis.
The descriptive phase of glycosphingolipid biochemistry has blossomed over the past decade with the application of exquisitely sensitive analytical methods of mass spectrometry, NMR, and monoclonal antibody technology. Consequently, appreciation of the interrelation among the complex carbohydrate structures that are expressed on the cell surface has focused attention on the regulation of the gl...
متن کاملRegulation of membrane-bound enzymes of glycosphingolipid biosynthesis
Abatract T h e descriptive phase of glycosphingolipid biochemistry has blossomed over the past decade with the application of exquisitely sensitive analytical methods of mass spectrometry, NMR, and monoclonal antibody technology. Consequently, appreciation of the interrelation among the complex carbohydrate structures that are expressed on the cell surface has focused attention on the regulatio...
متن کاملGlycosphingolipid functions.
The combination of carbohydrate and lipid generates unusual molecules in which the two distinctive halves of the glycoconjugate influence the function of each other. Membrane glycolipids can act as primary receptors for carbohydrate binding proteins to mediate transmembrane signaling despite restriction to the outer bilayer leaflet. The extensive heterogeneity of the lipid moiety plays a signif...
متن کاملInhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells.
Madin-Darby canine kidney (MDCK) I and Fisher rat thyroid (FRT) cells exhibit transepithelial electrical resistance (TER) values in excess of 5,000 Omega. cm(2). When these cells were incubated in the presence of various inhibitors of sphingolipid biosynthesis, a >5-fold reduction of TER was observed without changes in the gate function for uncharged solutes or the fence function for apically a...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1991
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.3.152